Please Teacher! is a story mainly revolving around a tight-knit group of friends in high school and how they cope with several life-changing events that are never too far off from intimate relationships. The main character is a boy named Kei Kusanagi who suffers from a very rare disease which causes a comatose state referred to as a "standstill" whenever he is under severe emotional distress. Before the beginning of the story, Kei, at 15 years old, had fallen into a "standstill" lasting three years after witnessing the suicide of his elder sister. After recovering, he quietly moved away from home in order to avoid social difficulty due to his long absence, and began living with his uncle, a medical doctor, and aunt. Due to the strange nature of how he came to live there, Kei wanted to keep the situation a secret from his new friends for fear of being ostracized as being too old to associate with them.